Scientist, Pharmacometrics at Johnson & Johnson in Spring House, PA
Key
Responsibilities:
Support high impact product development projects in all stages of drug development using mechanism and physiologically-based PK/PD modeling and simulation methodologies, including QSP modelling, physiological based pharmacokinetic (PBPK) modeling, disease progression modelling and model-based landscape analysis, etc. Demonstrate high proficiency in the development and application of models to address drug-discovery and development questions. Perform exploratory modelling projects with quick turnaround to support critical business decisions. Provide leadership to and collaboration with multidisciplinary project teams to develop and apply QSP models. Supervise and actively participate in the review and monitoring of outsourced modeling activities conducted at Contract Research Organizations (CROs). Guide and supervise junior scientists in the group. Serve as a point-of-contact person on QSP project teams, work in close collaboration with key Therapeutic Area (TA) stakeholders, clinical teams and related functional groups to maximize the value of mechanistic and QSP modeling. Provide scientific and strategic expertise across TAs (Immunology, Oncology, Cardiovascular and Metabolism, Neuroscience, Infectious Diseases and Vaccine) and promote model-informed drug discovery and development strategies. Qualifications A minimum of a Ph.D. degree in Pharmaceutical Sciences, Systems Biology, Pharmacology, Mathematics, Engineering, or a related disciplines related. Experience in using a quantitative approach in describing biological systems and quantitative tools to enable rational and efficient drug development is required. Strong understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, and ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways and systems is required. Proficiency in advanced PKPD modeling and simulation software (e.g. Matlab/Simbiology, Julia, Python, NONMEM, Monolix, etc.) is required. Experience in building, validating and using QSP models or deterministic models of biological pathways/systems to support basic science and/or translational clinical research is strongly preferred. Good understanding of the basic principles of Pharmacokinetics and Pharmacodynamics for conventional large and small molecule therapeutics as well novel therapeutic modalities is preferred. Experience with general programming and data analysis tools/languages (e.g. R, SpotFire, SQL) is preferred. Strong record of publications preferred. Must have excellent oral and written communication skills. Must be a self-motivated team player who excels in a collaborative, multi-disciplinary team environment. The ability to interact and collaborate effectively with scientists in other disciplines is required.
Salary Range:
$80K -- $100K
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
Responsibilities:
Support high impact product development projects in all stages of drug development using mechanism and physiologically-based PK/PD modeling and simulation methodologies, including QSP modelling, physiological based pharmacokinetic (PBPK) modeling, disease progression modelling and model-based landscape analysis, etc. Demonstrate high proficiency in the development and application of models to address drug-discovery and development questions. Perform exploratory modelling projects with quick turnaround to support critical business decisions. Provide leadership to and collaboration with multidisciplinary project teams to develop and apply QSP models. Supervise and actively participate in the review and monitoring of outsourced modeling activities conducted at Contract Research Organizations (CROs). Guide and supervise junior scientists in the group. Serve as a point-of-contact person on QSP project teams, work in close collaboration with key Therapeutic Area (TA) stakeholders, clinical teams and related functional groups to maximize the value of mechanistic and QSP modeling. Provide scientific and strategic expertise across TAs (Immunology, Oncology, Cardiovascular and Metabolism, Neuroscience, Infectious Diseases and Vaccine) and promote model-informed drug discovery and development strategies. Qualifications A minimum of a Ph.D. degree in Pharmaceutical Sciences, Systems Biology, Pharmacology, Mathematics, Engineering, or a related disciplines related. Experience in using a quantitative approach in describing biological systems and quantitative tools to enable rational and efficient drug development is required. Strong understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation, including numerical methods, parameter estimation/optimization, and ordinary differential equations (ODEs), and how these can be applied in the development of complex models of biological pathways and systems is required. Proficiency in advanced PKPD modeling and simulation software (e.g. Matlab/Simbiology, Julia, Python, NONMEM, Monolix, etc.) is required. Experience in building, validating and using QSP models or deterministic models of biological pathways/systems to support basic science and/or translational clinical research is strongly preferred. Good understanding of the basic principles of Pharmacokinetics and Pharmacodynamics for conventional large and small molecule therapeutics as well novel therapeutic modalities is preferred. Experience with general programming and data analysis tools/languages (e.g. R, SpotFire, SQL) is preferred. Strong record of publications preferred. Must have excellent oral and written communication skills. Must be a self-motivated team player who excels in a collaborative, multi-disciplinary team environment. The ability to interact and collaborate effectively with scientists in other disciplines is required.
Salary Range:
$80K -- $100K
Minimum Qualification
Life SciencesEstimated Salary: $20 to $28 per hour based on qualifications.
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