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Principal Scientist, Cardiovascular & Metabolism, In Vivo Pharmacology

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies is recruiting for an Principal Scientist, located in Spring House, PA.
At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.
Janssen Research & Development, LLC discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit http://www.janssenrnd.com/ for more information.
We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.
The successful candidate will be joining the In vivo Pharmacology team and will lead and direct the execution of multiple projects with focus on the areas of metabolism, NASH/kidney disease and/or cardiovascular disease. The Principal Scientist will use emerging developments in these fields to generate novel target ideas and provide technical and strategic input with the goal of progressing novel drug candidates into clinical development and beyond. The qualified candidate will work in cross-functional teams, including translational medicine, discovery, biomarker teams, program project teams and disease-specific working groups, to shape a discovery and pharmacology strategy for novel drug candidates and will bring forward novel translational animal models and innovative technologies to support long-term plans. Additional responsibilities include but are not limited to:
Plans and/or performs studies in various in vivo models to evaluate therapeutic agents for cardiovascular and metabolic diseases.
Plays a significant role in defining strategy and in vivo pharmacology processes for discovering and developing novel therapeutic agents.
Leads the design and implementation of multiple complex research plans as part of the overall discovery strategy.
Responsible for validity, reproducibility interpretation and statistical analysis of preclinical study data. Analyzes highly complex issues and significantly improves, changes or adapts existing methods and techniques
Develops research solutions that require extensive synthesized analysis, detailed investigation, and uncovers new approaches
Frequently interacts with senior internal and external colleagues often requiring coordination across multiple functions and groups.
Interprets and integrates data to make recommendations for critical discovery/technology project decisions.
Works under limited supervision with a high level of autonomy
Directs teams and sets project objectives for individual team members
May supervise/manage Ph.D. and non-Ph.D. scientists
Demonstrates excellent oral, written and interpersonal skills and is a strong collaborator.
Ph.D. degree in the life sciences with a post-doctoral fellowship in liver or kidney biology, or in fibrosis-related signaling with at least 2 years post fellowship OR a Ph.D. degree in the life sciences with at least 5 years relevant experience OR a MS degree in the life sciences with at least 10 years relevant experience is required
Academic faculty or industry experience is preferred
Demonstrated understanding and experience in performing pharmacological and mechanistic studies in in vivo models of metabolic disorders is required
Expertise in liver and/or kidney physiology and mechanisms leading to metabolic disease is required
Understanding of the overall process of drug discovery and development is preferred
Peer reviewed publication record in relevant fields
Working knowledge of pharmacology principles is required
Demonstrated understanding and established level of expertise evaluating preclinical models of metabolic disease is required
A background in in vivo models in metabolic and/or cardiovascular disease models is required
Experience is Chronic Kidney Disease, NASH and/or Fibrosis is preferred

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