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POSTDOCTORAL FELLOW-AAV ENGINEERING, PROMOTER DESIGN AND PRODUCTION DEVELOPMENT

Janssen BioTherapeutics is seeking
a highly motivated individual to support development of AAV production
platforms, capsid engineering, and vector technology in which to leverage this knowledge
to improve our AAV gene therapy program.
For
consideration as a post-doctoral fellow, the successful candidate will be a
subject matter expert on the development of AAV-based gene therapies. The
candidate will have experience in viral vector design, characterization, and
production platforms. The position will
be responsible for developing novel capsid engineering for improving target
cell tropism as well as characterizing viral vectors in support of gene therapies
across a broad range of targets. Towards this end, a fundamental
understanding of evaluating expression profiles of therapeutic targets will be
required. The ability to interact with external
stakeholders and to subsequently apply that knowledge towards developing a
world-class gene therapy program is critically important
At Janssen, postdoctoral fellows
are trained by expert scientists working at the cutting edge of drug
discovery. Janssen Bio Therapeutics
supports a wide range of therapeutic areas including Oncology, Neuroscience,
Cardiovascular and Metabolism, Immunology, and Infectious Diseases. The successful candidate will learn from and
contribute to an industry-leading drug discovery program that has brought
numerous quality therapeutics to patients and significant contributions to
human health. They will partner
throughout the Janssen R&D organization and participate in cross-functional
team discussions, gaining insight into many aspects of biotherapeutic discovery
and development. The Postdoctoral Fellow
is expected to author papers on their research and present novel findings at scientific
conferences.
Key
Objective:
To use state-of-the-art cell
engineering, gene expression technologies, and protein purification methods to gain
a better understanding into basic AAV biology and viral production systems.
Qualifications
Qualifications
Suitable candidates should be
highly motivated, independent thinkers with a Ph.D. in virology, molecular or
cell biology, cell engineering or a related field. Research experience or knowledge in one or
more of the following areas is preferred:
+ Gene
editing technologies such as CRISPR or CRISPR screening
+ Basic
molecular techniques with excellent working knowledge of how to work with
protein and nucleic acids.
+ Knowledge
of AAV capsid structure or design approaches
+ Knowledge
of AAV Biology
+ Experience
working with AAV
+ Excellent
cell culture skills
Candidates
must display an ability to independently design and execute research. In
addition to a broad knowledge of cell and molecular
biology, we are seeking an individual with deep intellectual curiosity, and
excellent communication and interpersonal skills.
Primary Location
United States-Pennsylvania-Spring House-
Organization
Janssen Research & Development, LLC. (6084)
Job Function
Administration
Requisition ID
6056181030

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