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Senior Scientist, X-ray Crystallography

Janssen Research &
Development, L. L. C., a division of Johnson & Johnson's Family of Companies
is recruiting for a Senior Scientist, X-ray
Crystallography, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters
most is helping people live full and healthy lives. We focus on treating,
curing and preventing some of the most devastating and complex diseases of our
time. And we pursue the most promising science, wherever it might be
found.

Janssen Research & Development, LLC discovers and develops innovative
medical solutions to address important unmet medical needs in oncology,
immunology, neuroscience, infectious diseases and vaccines, and cardiovascular
and metabolic diseases. Please visit http://www. janssenrnd. com/ for more
information.

The Lead Discovery group is a critical part of the Discovery Sciences (DS)
organization in Janssen R&D; and is committed to the delivery of high
quality chemical starting points needed for the generation of small molecule
clinical compounds in all five Janssen Therapeutic Area (TA) discovery teams.
This mission requires deep scientific expertise in a number of disciplines
including chemistry, cellular and molecular pharmacology, enzymology, HTS, and
structural biology coupled with an ability to work collaboratively with
internal and external partners. Building on a strong legacy of success, we are
currently seeking an outstanding individual to join our team as Senior Scientist,
X-ray Crystallography.
The Senior Scientist will:

  • Be
    responsible for crystallization of protein-small molecule complexes and
    determination of high-resolution structures by x-ray crystallography
  • Work closely with protein
    scientists, biophysicists and protein NMR scientists as part of an integrated
    structural biology effort
  • Bring in-house innovative structural
    biology technologies
  • Be a member of drug
    discovery teams, working closely with computational and medicinal chemists on
    structure-based drug design approaches for small molecule agent optimization
  • Contribute to
    multidisciplinary Fragment-Based Lead Discovery (FBLD) efforts
  • Contribute to increase the
    structural biology scientific expertise of the group by publishing high-impact
    research papers and establishing academic collaborations
  • Mentor lab scientists and
    contribute to the strategic planning of the Structural Biology group
Qualifications
  • Ph. D.
    or equivalent with postdoctoral experience in structural biology (x-ray
    crystallography or protein NMR) or a related field is required
  • Deep
    scientific expertise in structural biology is required
  • Strong
    experience in both protein crystallization and high-resolution structure
    determination is required
  • A
    minimum of 5 years of drug discovery experience with a record of important
    contributions to programs is required
  • Experience
    in Structure Based Drug Design (SBDD) utilizing x-ray crystallography is
    required
  • Strong
    record of external publications and presentations is required
  • Outstanding
    written and oral presentation skills is required
  • Experience
    in scientific programming (Unix shells, Python, Perl), and ability to work with
    the latest relevant software packages and in a mixed Linux/Windows computational
    environment is preferred
  • Research
    experience in biophysics, biochemistry, molecular pharmacology, and protein
    sciences is preferred
  • Research
    experience in cryo-electron microscopy (Cryo-EM) and other novel structural
    biology technologies is preferred
  • Line
    management experience is preferred
  • Expertise in one or more of the following therapeutic areas: Oncology,
    Inflammation, Neuroscience, Cardiovascular, and Infectious Diseases is preferred

Johnson & Johnson is an Affirmative
Action and Equal Opportunity Employer. All qualified applicants will receive
consideration for employment without regard to race, color, religion, sex,
sexual orientation, gender identity, age, national origin, or protected veteran
status and will not be discriminated against on the basis of disability.



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