Associate Scientist II - Immuno-Oncology Cell Therapy (1 of 4)

Janssen Research &
Development, LLC, a member of the J&J; Family of Companies, is recruiting
for an Associate Scientist II Immuno-Oncology Cell Therapy position located in
Spring House, PA. This position will require up to 10% domestic

At the Janssen
Pharmaceutical Companies of Johnson & Johnson, what matters most is helping
people live full and healthy lives. We focus on treating, curing and preventing
some of the most devastating and complex diseases of our time. And we pursue
the most promising science, wherever it might be found.

We discover and develop
innovative medical solutions to address important unmet medical needs in
oncology, immunology, neuroscience, infectious diseases and vaccines, and
cardiovascular and metabolic diseases.

We are Janssen. Our
mission drives us. Our patients inspire us. We collaborate with the world for
the health of everyone in it. Bring your talents to our mission, visit
http://www. janssenrnd. com/ to learn more.

We are Janssen. Our
mission drives us. Our patients inspire us. We collaborate with the world for
the health of everyone in it.

The Associate
Scientist will join the Cellular Therapy team within the Immuno-Oncology group
at Janssen with a focus on CAR-T therapy. S/he will be lab-based and will be
responsible for generating large volumes of accurate, highly reproducible
functional data to support late stage assets for regulatory submission, as well
as support validation biology and MOA to understand mechanisms of resistance,
exhaustion, and persistence.

The Associate
Scientist will work with limited supervision to independently design, schedule, run, and interpret complex in vitro, ex vivo and in vivo experiments. S/he must be
a fast learner, be extremely organized, possess a sense of urgency, and be able
to manage multiple experiments simultaneously.

The position resides
in a highly matrixed team environment so a collaborative spirit, excellent
written and verbal communication skills, and strong interpersonal skills are
necessary and highly-valued. S/he will contribute to various projects outside
of her/his own, collaborate with stakeholders from all relevant functions, and
keep up-to-date with documentation and published literature related to
the field.

  • Bachelors
    with up to 4 years of experience, performing progressively advanced duties
    at the Associate Scientist I level, or Masters with 5 years of experience
  • Recent
    lentivirus and CAR-T experience is preferred
  • Strong
    tissue culture experience in human and mouse ex vivo tissues, primary
    immune cells and tumor cell lines is required
  • Previous
    recent experience in isolating, activating and differentiating human
    immune cells (T cells, Tregs, monocyte derived DCs) and T cell killing
    assays is required
  • Prior experience designing and running 10+ color
    flow panels is required
  • Meticulous
    documentation (Accelrys Electronic Lab Notebook and OpenLab ECM), mastery
    of analysis software (GraphPad Prism v6. 02 or greater, FlowJo v10. 5 or greater,
    TIBCO Spotfire) familiarity with data sharing platforms (Sharepoint, One
    Drive) is desirable
  • Proficiency
    with AutoMACS, FCS, Luminex, MSD, Ella and ELISA experience is preferred
  • A
    strong background in cell biology, immunology, cancer biology and assay
    development skills is required
  • This
    position is located in Spring House, PA with up to 10% domestic travel

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