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Senior Scientist-Colorectal Cancer Interception

In the Senior Scientist role, you will support pre-clinical drug discovery programs for Colorectal Cancer Interception within the Oncology Therapeutic Area of Janssen. This position involves lab-directed efforts to support and lead novel target validation and early drug discovery, with both internal and external partners. Specifically, you will work on and lead programs to initiate novel efforts for validation and early drug discovery in exploratory platforms, pathways, and disease treatment paradigms. Experimental work is an important part of the role and you will spend a significant part of your time at the bench and demonstrate rigorous data documentation and analysis skills. To be a prospective candidate for this role, you should have at least 5-10+ years of bench experience working within a drug discovery program. You are required to have experience supporting and leading programs that have moved from preclinical through clinical development.   Qualifications Technical Skill requirements include: Molecular assays (Western blot, qPCR/RT-PCR, pTyr assays and pathway analysis) Flow cytometry (multi-parameter cytometry, profiling experience is a plus) Design, develop and implement in vitro assays including, but not limited to, binding, signaling, activation, cytokine release, and enzymatic activity. Cellular assays (tissue culture, cytotoxicity/killing, experience with spheroid/organoid work is a plus) You will work independently to understand, analyze, and interpret data and communicate results in Powerpoint presentations to align with Colorectal Cancer Interception strategies Additional responsibilities include assay trouble shooting and development of new technology platforms. Experience working in multidisciplinary teams is required, and will require excellent interpersonal skills, and a strong ability to present data in an organized fashion. You will need to perform meticulous record keeping and generate scientific reports to support preclinical drug development. Ability to contribute to documents to support IND filings, patent applications, external conference posters and journal articles is preferred. Requirements: Ph.D. degree in a biology-related field 5-10+ years of laboratory experience in a pharmaceutical setting supporting drug discovery efforts including programs in Oncology Drug development experience, particularly around small molecule programs, is required. Preclinical pharmacology experience required including design and conduct using models of disease. Colorectal cancer expertise in areas such as microbiology, immunology, oncology, cell and/or molecular biology expertise is preferred. Working knowledge of Microsoft Office programs (Excel, Powerpoint), FlowJo, Graphpad Prism, Spotfire, and other data management systems. Must have exceptional written and oral communication skills, strong troubleshooting ability and organization skills, and a strong publication record in peer-reviewed journals. Requisition ID: 6925181108
Salary Range: NA
Minimum Qualification
5 - 7 years

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