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Principal Scientist, Molecular Biologist / Innovationist

The Principal Scientist position is a leadership position within the Biologics Discovery team.  The successful candidate will drive biologics discovery in partnership with different therapeutic areas (TA) including oncology, immunology, metabolic diseases, neurology and infectious diseases. As a scientific leader in the department, the Principal Scientist will interact with other functional areas to provide molecular design for biologics therapeutics including antibody & protein therapeutics, cell-based therapies including CAR-T, and viral-packaged therapeutics. The positions responsibilities also include therapeutic portfolio project leadership and cutting-edge molecular biology technology development.   The scope of this position encompasses: Designing sequences and vectors to support all large molecule, cell- and viral-based therapeutics Selecting, designing and humanizing domain-modules/scFv/Fab from antibodies for multi-specific formatting including for CAR-T and viral-delivery therapeutics Leading portfolio project(s) from idea through IND-readiness in partnership with therapeutic area leadership Executing molecular biology, such as in silico sequence fitness assessments, PCR-based cloning, construct design, library and/or site-directed mutagenesis for the much of the biologics portfolio Developing high-sensitivity, high-throughput assays (protein and/or cell-based) for antibody and cellular therapeutics to select leads with excellent biophysical and manufacturing properties with reduced immunogenic potential Leading and supervising research activities of bench scientist(s) Presenting and defending scientific findings in cross-functional project teams/initiatives, drafts protocols and reports Qualifications PhD in molecular biology, biochemistry, biophysics, immunology or a related discipline with a minimum of 5 years of experience is required Evidence of material scientific accomplishments such as a peer-reviewed publication is required Demonstrated knowledge of Molecular Biology techniques is required Understanding of high-throughput construct design, restriction-free and restriction-based cloning is preferred Discovery of antibody-based biotherapeutics in an industry or academic setting is preferred A minimum of two years of supervising individuals in a laboratory setting is preferred   Leading a project to completion or championing a technology initiative including matrixed programs is preferred Hands-on experience with multi-specific and/or CAR-T scaffold design, engineering and profiling is preferred Hands-on experience with display & library technologies for discovery and/or humanization & optimization is preferred Clear communication skills in writing and presentation 2443180920
Salary Range: NA
Minimum Qualification
5 - 7 years

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